A study was conducted to determine the effect of ethanolic extracts of propolis collected by bees from Tapachula, Chiapas on the development of 225 juvenile tilapia (Oreochromis niloticus), fed in commercial starter feed in one of five daily rations with different concentrations: T0 (0 g Kg-1), T1 (10 g Kg-1), T2 (15 g Kg-1), distributed for 4 weeks in 9 containers of 60 l each. Tilapia growth was evaluated through morphometric data such as weight (g), total length (cm), and standard length (cm) for each week in order to identify changes. Physicochemical parameters were measured in the water, such as temperature (°C), salinity (ppm), electrical conductivity (uS/m), total dissolved solids (ppm), pH, and total ammonium (mg/L). Significant differences (p<0.05) were found between treatments in the different weeks evaluated, and it was T1 that showed the greatest positive effect on fish development. The physicochemical parameters that explain 72% of the behavior of the treatments were salinity, total dissolved solids, and electrical conductivity. It is concluded that ethanolic extracts of bee propolis (Apis mellifera) from the lower zone of Tapachula, administered in feed, can promote the development of juvenile tilapia (Oreochromis niloticus) under experimental conditions.