Jaundice is a widespread disease in neonates and adults, and it is particularly prevalent in underdeveloped countries. It is linked to the most common liver disorders due to the dysfunction of the liver, such as hepatitis and cirrhosis, and can be associated with factors like viral infections and autoimmune disorders. The data concerning aspects of our study were extracted using the terms “Jaundice, Causative factor, Traditional medicine, Pharmacological activities, Bioactive constituents”. Various search engines, such as PubMed, Google, Scopus, Google Scholar, Science Direct, and Web of Science, were used (2017-2025). This review shows that approximately 34 medicinal plants used by tribal and rural inhabitants of India are used to treat jaundice. In Ayurveda, herbs such as Arogyavardhini Vati, Punarnava, and Bhumyamalaki are commonly used for the treatment of jaundice due to their hepatoprotective properties, which aid liver detoxification. Amongst all the plant species, the most effective traditional plants for treating jaundice include E. ribes, H. helix, J. adhatoda, B. aristata, A. vera, and T. cordifolia. These traditional medicinal systems often combine multiple herbs to create formulations that target various aspects of jaundice, from reducing bilirubin levels to promoting liver health. Some of these herbal compounds have shown promising results in preclinical studies, and clinical trials are underway to assess their safety and efficacy. While modern medical treatments for jaundice, such as phototherapy and medications, have proven efficacy, ethno-pharmacological approaches offer alternative options, particularly in regions where access to advanced healthcare is limited.
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