World Journal of Environmental Biosciences
World Journal of Environmental Biosciences
2024 Volume 13 Issue 2

Characterization of Defatted Cake Prepared from Egyptian Olive's Fruit (Wateeken Cultivar) and Its Biological Activity


  1. Department of Fats and Oils, National Research Center (NRC), Cairo, Egypt.

Abstract

In the current study, we characterized the components of a defatted cake prepared from Egyptian olive fruit (Wateeken cultivar) (DCEOF), its phenolic and squalene content, and evaluated its biological activities as radical scavenger capacity, anti-inflammatory, antitumor, and mechanism of action via apoptotic effect.  Data obtained showed that methanolic extract showed a high content of phenolic, short-chain fatty acids, and retinol; a derivative of vitamin A. The mean level of squalene was (490±45) while the mean total phenolic level was (5.76 ±1.5). The extract showed anti-inflammatory activity as measured by inhibition of Albumin denaturation (44.4%) and antiproteinase Activity (92.6%). In addition, the  defatted olive cake extract exhibited antiproliferation against  HepG2 cells following treatment with different concentrations of extracts  (0-200 µg/ml) for 24, 48, and 72 hours. It demonstrated that, after 24 hours, the inhibition percent was increased with dose-dependent ( IC50 was 100 mg /ml ). The inhibition rate reached maximum after 48 hours and decreased after 72 hours.   The apoptotic markers caspase 3 and 9 were increased 2-4 times in response to defatted olive cake extract. It was concluded that the defatted olie cake of Wateeken cultivar is promising as anti-inflammatory, antitumor activity, and apoptotic activity with high nutritional value with low side effects.


How to cite this article
Vancouver
Singar FAW. Characterization of Defatted Cake Prepared from Egyptian Olive's Fruit (Wateeken Cultivar) and Its Biological Activity. World J Environ Biosci. 2024;13(2):31-5. https://doi.org/10.51847/R7K4g1FOdt
APA
Singar, F. A. W. (2024). Characterization of Defatted Cake Prepared from Egyptian Olive's Fruit (Wateeken Cultivar) and Its Biological Activity. World Journal of Environmental Biosciences, 13(2), 31-35. https://doi.org/10.51847/R7K4g1FOdt
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