In previous literature, several studies have highlighted both harmful and beneficial effects of electromagnetic fields for human beings and, in particular, possible applications for the treatment of some diseases. In this regard, we hypothesize that a possible application of beneficial effects of electromagnetic fields can be represented by irradiating lethal viruses such as SARS-CoV-2 by electromagnetic fields at frequencies close to the natural resonant frequencies of virus capsid and genome, inducing a relevant harmful alteration in its structure. Exposure of weakened virus samples to high-frequency electromagnetic fields at a frequency ranging from 1 to about 40 GHz, for instance, can be carried out by a variable frequency voltage generator and a signal amplifier to detect frequencies at which amplification of Amide and phosphate vibration bands occurs that should induce virus inactivation. FTIR spectroscopy can be used to evaluate the results of exposure. Amide I and II modes and phosphate vibration bands are characteristic of virus capsid and genome, respectively, so that their amplification at a resonant frequency should induce virus damage. Once resonance frequency of SARS-CoV-2 is found for one of its structures, living human spaces can be irradiated by electromagnetic radiation at such frequency to decontaminate not only surfaces but in particular air, contrary to what common disinfectants can do. This methodology could be implemented quite quickly pending the long time required for vaccinations.