Recent recommendations state that considerable coronary artery disease (CAD) should be treated before the index procedure in patients with severe aortic stenosis who have a transcatheter aortic valve implant. However, the data supporting this suggestion is still limited. We aimed to assess the recent updates on percutaneous coronary intervention (PCI) among patients undergoing transcatheter aortic valve interventions. A search was performed on the PubMed, Web of Science, Science Direct, EBSCO, SCOPUS, Wiley, and Cochrane Library databases. Study articles were screened by title and abstract using Rayyan QCRI then a full-text assessment was implemented. A total of eleven studies with 6252 patients were included. The self-expandable (SE), balloon-expandable, Edwards Sapien (ES), and CoreValve are the most common valve types used in TAVI or TAVR. Most of the included studies reported that TAVI/ TAVR combined with the PCI technique is a safe and efficacious procedure for managing patients with AS. For patients with severe AS and with or without CAD, combined PCI prior to TAVI/ TAVR is a relatively safe and practical method, according to the available evidence on short- and mid-term results.
