This study predicted yield in wheat cultivars with different maturity and planting date, and resistance to yellow rust. The highest yield ranking was detected for the earliest planting date (October) with a yield improvement of 184.55% compared to the latest planting date (January). The highest and lowest yield ranks were determined for the first year (2013-2014) and fourth year (2016-2017), respectively. The first main factor identified the interaction of yellow rust development with the number of rainy days in spring. The maturity planting date and yield predictors contributed to the second factor. The third factor related the resistance index to the Gaussian parameter b of disease development. The regression model justified 90% of the variations in wheat yield. Early planting dates, more rainy days in spring, late maturity of the cultivar, late disease onset, and higher wheat resistance were responsible for the higher yields. Such findings contribute to the future epidemiology of yellow rust, breeding programs for resistant genotypes, and wheat yield estimation.