This research attempted to predict yield in wheat cultivars varying in maturity and planting date, and resistance to yellow rust. The highest yield ranking was detected for the earliest planting date (October) with yield being improved by 184.55% compared to the latest planting date (January). The highest and lowest yield rankings were determined for the first (2013-2014) and fourth (2016-2017) years of study, respectively. The first principal factor detected the interaction of yellow rust progress with several rainy days in spring. Maturity planting date and yield predictors contributed to the second factor. The third factor linked the resistance index to Gaussian parameter b of disease progress. The regression model justified 90% of variations in wheat yield. Early planting dates, further rainy days in spring, late maturity of cultivar, late disease onset, and greater wheat resistance were responsible for higher yields. Such findings assist with the future epidemiology of yellow rust, breeding programs for resistant genotypes, and estimation of wheat yield.