In brain tumors, the advanced treatment options techniques mostly depend on radiotherapy and neurosurgery, it also revolves around several factors including the type of tumor, extent, and location that are demonstrated by modern magnetic resonance imaging and positron-emission tomography scan. These modalities have high variability and lack method standardization application. The objectives of this review are to present an overview of many evidence-based published studies on neurosurgical and radiotherapeutic management of brain tumors. This review had a wide-ranging research literature strategy. PubMed electronic databases were the basic citation resources. Initially, the management of brain tumors should be analyzed by a multidisciplinary team (radiation oncology, medical oncology, and neurosurgery) based on the mentioned factors affecting the condition. In Whole brain radiotherapy radiologists are serving as a basic component in the primary treatment for brain metastases in patients with expected higher survival rates and lower recurrence after stereo static resection surgery. The alternative for WBRT is performing hypofractionated radiation therapy, in cases that are not susceptible to perform radiosurgery or surgery. However, dosing in hypofractionated radiation therapy is still controversial.