Phthalic esters are an important group of chemical agents mainly used as plasticizers and solvents. This study was designed to investigate the effects of DIETHYL phthalate (DEP) which is one of the phthalatic esters on the evaluation parameters. Blood can be used to explain the blood-related functions that can act as a pathological reflector and an indicator of the physiological state of animals, and it can also be used to assess liver enzymes such as (AST) and (ALT) which are considered to evaluate the changes in liver function and therapeutic potential of palm pollen grains (DPP) by these parameters. In a group of male rabbits (DEP) which were treated orally with a dose of (330 ml / kg / day) for 30 days, toxic effects on the haematological parameters such as hemoglobin (HB), hematocrit (HCT) and erythrocytes (RBC) were decreased. It was also noticed a significant increase in rates (ALT) and (AST) in the same group. The group of rabbits which were treated with the combination of DEP and DPP by successive doses (240mg / kg / day) and (330 ml / kg / day) showed an improvement in all of the parameters studied. These findings supported the hypothesis that the two functions of the blood and liver are particularly sensitive to DEP treatment, with DPP can mitigate the deleterious effects of DEP probably by activating the endocrine and antioxidants system.