Our study is on the Spatio-temporal distribution of the Berber Toad Amietophrynus mauritanicus (Anura: Bufonidae), in the perimeter of the K'sob (35° 43° 21° North 4° 33° 35° East), which is located on the northern side of the wilaya of M'Sila, at an altitude of 490 m. This study aims to have a general overview of the ecology of the species in a semi-arid bioclimate, case of the K'sob perimeter in the wilaya of M'Sila. The study of the spatio-temporal distribution of the Berber Toad Amietophrynus mauritanicus, during the years 2015 and 2016, consists of monthly outings to three selected environments (agglomeration, cultivated environment, and natural environment). The results show the abundance of the Berber toad in the summer period followed by autumn and spring (respectively: 37.8%, 32.1%, and 30.1%, respectively). While in winter, nothing was recorded for this species of toad. However, the Berber toad is abundant, in spring, in both natural (66.7% - 38.5%) and cultivated environments (41.7% - 46.2%). In the Agglomerations, the rates are high during the summer (42.3% - 37.5%) and autumn (42.3% - 45.8%). It is concluded that the rates of the Berber toad in the K'sob perimeter vary in the three environments according to the seasons except in winter.