Atopic dermatitis is a common disease that affects all age groups. The disease is on the rise worldwide. There is an increasing concern regarding its association with autoimmune diseases. Literature regarding this important issue lacks. This meta-analysis aimed to assess the association of AD with autoimmune disorders. An electronic literature search was conducted in the PubMed, Cochrane Library, in addition to the first 100 articles in Google Scholar during the period from 2010 up to January 2021. Five hundred forty-three references and abstracts were identified, of them, 8 full texts were screened. While only four studies fulfilled the inclusion and exclusion criteria. The keywords used were atopic dermatitis, atopic eczema dermatitis syndrome, autoimmune disease, skin autoimmunity, gastrointestinal autoimmune diseases to include most of the systematic autoimmune disorders. The current meta-analysis included four studies with 1735789 patients and 14927 events. The studies were published in Asia and Europe. All were retrospective studies with study periods ranging from five years to 48 years. Autoimmune diseases were higher among patients with AD, a significant statistical difference was observed (odds ratio, 1.61, 95 % CI, 1.05-2.45, P-value, 0.03). The random effect was applied due to the substantial heterogeneity observed (I2=98%, P-value<0.001). Autoimmune disease was commoner among patients with AD compared to their counterparts without the disease.