The use of pesticides becomes an indispensable technique for most agricultural practices, whatever the level of country development. At present, the pesticides used are often less toxic and more specific and are based on insect physiology. Recent studies indicate that pesticide intoxication induces oxidative stress.
This work aims to study the neuro-behavioral consequences of the administration of two insecticides currently widely used in agriculture: spirotetramat (inhibitor of lipid synthesis in insects) and ethanol extract of Citrullus colocynthis (endemic plant of the Algerian Sahara). The different behavioral tests (raised cross labyrinth, open fields and forced swimming) show that both pesticides had a significant impact on rodent’s anxiety degree. These products significantly influence the biochemical parameters (glycemia, cholesterol, triglycerides, urea, creatinine), the ACTH hormone and acetylcholine esterase (AChoE)