The current management is still controversial and depends upon understanding the complex pathophysiological and etiological factors. There have been several theories that proposed the initial process regarding polyps’ formation. Confirming the diagnosis of nasal polyps requires endoscopic investigations or complex radiological investigations. However, currently available medications are mostly based upon clinical experience that describes these pathophysiological and etiological hypotheses. This review provides a wide view on the current evidence-based diagnosis and management abilities in Nasal polyp’s conditions, to fully be able to help and aid ENT clinicians to provide good medical compliance throughout the medication process. This review was classified and collected from eligible publicized only English written extracts, articles, and advanced clinical trials. These electronic research engines were included: PubMed and Google Scholar database. Keywords were used together in combination. Treating nasal polyps is directed to relieve symptoms and upgrade therapeutic management to provide the best results of care. The role of endoscopic surgical therapy is highly effective in treating chronic rhinosinusitis if the palliative medical management is found ineffective.