TY  - JOUR
T1  - Multiple Sclerosis flare-ups Diagnostic and Management Approach in Emergency Department, Review Article
A1  - Nawaf Saad Alrusayyis
A1  - Khaled Mohammed Alghamdi
A1  - Bassam Mana Alahmari
A1  - Ruba Mahmoud Barnawi
A1  - Ali Yousef A Alfuraydan
A1  - Bader Aziz Alharbi
A1  - Mohammed Salamah Alwaladali
A1  - Wed Abdulaziz Alamri
A1  - Razan Khalid Alqurashi
A1  - Ali Ghalib Alhashim
JF  - World Journal of Environmental Biosciences
JO  - World J Environ Biosci
SN  - 2277-8047
Y1  - 2021
VL  - 10
IS  - 4
DO  - 10.51847/NTYL4XWgmv
SP  - 9
EP  - 12
N2  - Multiple sclerosis is a chronic inflammatory autoimmune condition that causes axonal demyelination and neural dysfunction. It is the most prevalent non-traumatic disabling condition in young adults, with a prevalence of over 2 million cases worldwide. Patients are classified into different subtypes based on their clinical course. The majority of cases have the Relapsing-remitting form that is characterized by acute exacerbation also known as flare-ups. Which could have an immense toll on patients’ physical and emotional health. acute multiple sclerosis flare-ups and their management.PubMed database was used for articles selection, papers were then obtained and reviewed. Multiple sclerosis flare-ups can vary dramatically in their presentation and severity from one patient to other. Establishing a diagnosis of an acute flare-up is mainly clinical but could be supported by MRI findings of a gadolinium-enhancing lesion. Pseudo-relapses are a group of numerous conditions that can lead to acute worsening of the patient symptoms mimicking a true relapse, therefore physicians should take active measures to confirm the absence of such conditions. Treatment should be offered for patients with disabling symptoms or if impaired daily function. First-line therapies are glucocorticoids or ACTH injection gels as both have similar efficacy and relatively safe profile, as for irresponsive cases a trial of either plasma exchange or immunoadsorption could be tried.
UR  - https://environmentaljournals.org/article/multiple-sclerosis-flare-ups-diagnostic-and-management-approach-in-emergency-department-review-arti-eujusixmcs32qvf
ER  -