%0 Journal Article
%T Multiple Sclerosis flare-ups Diagnostic and Management Approach in Emergency Department, Review Article
%A Nawaf Saad Alrusayyis
%A ‏Khaled Mohammed Alghamdi
%A ‏Bassam Mana Alahmari
%A ‏Ruba Mahmoud Barnawi
%A ‏Ali Yousef A Alfuraydan
%A Bader Aziz Alharbi
%A Mohammed Salamah Alwaladali
%A Wed Abdulaziz Alamri
%A Razan Khalid Alqurashi
%A Ali Ghalib Alhashim
%J World Journal of Environmental Biosciences
%@ 2277-8047
%D 2021
%V 10
%N 4
%R 10.51847/NTYL4XWgmv
%P 9-12
%X Multiple sclerosis is a chronic inflammatory autoimmune condition that causes axonal demyelination and neural dysfunction. It is the most prevalent non-traumatic disabling condition in young adults, with a prevalence of over 2 million cases worldwide. Patients are classified into different subtypes based on their clinical course. The majority of cases have the Relapsing-remitting form that is characterized by acute exacerbation also known as flare-ups. Which could have an immense toll on patients’ physical and emotional health. acute multiple sclerosis flare-ups and their management.PubMed database was used for articles selection, papers were then obtained and reviewed. Multiple sclerosis flare-ups can vary dramatically in their presentation and severity from one patient to other. Establishing a diagnosis of an acute flare-up is mainly clinical but could be supported by MRI findings of a gadolinium-enhancing lesion. Pseudo-relapses are a group of numerous conditions that can lead to acute worsening of the patient symptoms mimicking a true relapse, therefore physicians should take active measures to confirm the absence of such conditions. Treatment should be offered for patients with disabling symptoms or if impaired daily function. First-line therapies are glucocorticoids or ACTH injection gels as both have similar efficacy and relatively safe profile, as for irresponsive cases a trial of either plasma exchange or immunoadsorption could be tried.
%U https://environmentaljournals.org/article/multiple-sclerosis-flare-ups-diagnostic-and-management-approach-in-emergency-department-review-arti-eujusixmcs32qvf